Article
Multi-omics subtyping pipeline for chronic obstructive pulmonary disease.
PloS one - 1 Jan 2021
Gillenwater Lucas A, Helmi Shahab, Stene Evan, Pratte Katherine A, Zhuang Yonghua, Schuyler Ronald P, Lange Leslie, Castaldi Peter J, Hersh Craig P, Banaei-Kashani Farnoush, Bowler Russell P, Kechris Katerina J
Abstract excerpt
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of mortality in the United States; however, COPD has heterogeneous clinical phenotypes. This is the first large scale attempt which uses transcriptomics, proteomics, and metabolomics (multi-omics) to determine whether there are molecularly defined clusters with distinct clinical phenotypes that may underlie the clinical heterogeneity....
Topics
- Age Factors
- Aged
- Cluster Analysis
- Databases, Factual
- Female
- Gene Expression Profiling
- Gene Expression Regulation
- Gene Regulatory Networks
- Humans
- Male
- Metabolomics
- Middle Aged
- Phenotype