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Article

Novel somatic alterations in unicentric and idiopathic multicentric Castleman disease.

European journal of haematology - 1 Dec 2021

Goodman Aaron M, Jeong Ah-Reum, Phillips Alexis, Wang Huan-You, Sokol Ethan S, Cohen Philip R, Sicklick Jason, Fajgenbaum David C, Kurzrock Razelle

Abstract excerpt

OBJECTIVES: Castleman disease (CD) is a heterogeneous group of disorders involving systemic inflammation and lymphoproliferation. Recently, clonal mutations have been identified in unicentric CD (UCD) and idiopathic multicentric CD (iMCD), suggesting a potential underlying neoplastic process. METHODS: Patients with UCD or iMCD with next generation sequencing (NGS) data on tissue DNA and/or circulating tumor DNA...

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Identifiers

PMID: 34431136
DOI: 10.1111/ejh.13702
PMCID: PMC9624446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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