Article
Joint associations of depression, genetic susceptibility and the area of residence for coronary heart disease incidence.
Journal of epidemiology and community health - 1 Mar 2022
Silventoinen Karri, Korhonen Kaarina, Lahtinen Hannu, Jelenkovic Aline, Havulinna Aki S, Ripatti Samuli, Salomaa Veikko, Davey Smith George, Martikainen Pekka
Abstract excerpt
BACKGROUND: Depression is a risk factor for coronary heart disease (CHD), but less is known whether genetic susceptibility to CHD or regional-level social indicators modify this association. METHODS: Risk factors of CHD including a Polygenic Risk Score (PRS) were measured for 19 999 individuals residing in Finland in 1997, 2002, 2007 and 2012 (response rates 60%-75%). During the register-based follow-up until...
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