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Identification of a Streptococcus parasuis isolate co-harbouring the oxazolidinone resistance genes cfr(D) and optrA

29 Jul 2021

Abstract excerpt

Oxazolidinones, such as linezolid and tedizolid, represent last-resort drugs for the treatment of serious clinical infections caused by MDR Gram-positive bacteria. To date, seven different acquired oxazolidinone resistance genes have been identified, including cfr, cfr(B), cfr(C), cfr(D), cfr(E), optrA and poxtA.1 The gene cfr(D), a cfr gene variant, codes for an rRNA methyltransferase that confers a similar...

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PMID: 34406409
DOI: 10.1093/jac/dkab297

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