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GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Oct 2021

Tsai Ming-Shao, Yang Yao-Hsu, Lin Yu-Shih, Chang Geng-He, Hsu Cheng-Ming, Yeh Reming-Albert, Shu Li-Hsin, Cheng Yu-Ching, Liu Hung-Te, Wu Yu-Huei, Wu Yu-Heng, Shen Rou-Chen, Wu Ching-Yuan

Abstract excerpt

Since the start of the outbreak of coronavirus disease 2019 in Wuhan, China, there have been more than 150 million confirmed cases of the disease reported to the World Health Organization. The beta variant (B.1.351 lineage), the mutation lineages of SARS-CoV-2, had increase transmissibility and resistance to neutralizing antibodies due to multiple mutations in the spike protein. N501Y, K417N and E484K, in the...

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Identifiers

PMID: 34388530
DOI: 10.1016/j.biopha.2021.112011
PMCID: PMC8339502

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