Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Idebenone protects against retinal damage and loss of vision in a mouse model of Leber's hereditary optic neuropathy.

PloS one - 1 Jan 2012

Heitz Fabrice D, Erb Michael, Anklin Corinne, Robay Dimitri, Pernet Vincent, Gueven Nuri

Abstract excerpt

Leber's hereditary optic neuropathy (LHON) is an inherited disease caused by mutations in complex I of the mitochondrial respiratory chain. The disease is characterized by loss of central vision due to retinal ganglion cell (RGC) dysfunction and optic nerve atrophy. Despite progress towards a bet...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Administration Schedule
Share to Electron Transport Complex I
Share to Intravitreal Injections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Optic Atrophy, Hereditary, Leber

Share to Retinal Ganglion Cells

Share to Rotenone

Share to Ubiquinone

Share to Visual Acuity

Source

Open in PubMed Open full text

Identifiers

PMID: 23028832
DOI: 10.1371/journal.pone.0045182
PMCID: PMC3445472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23028832-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Idebenone protects against retinal damage and loss of vision in a mouse model of Leber's hereditary optic neuropathy.PMID 23028832Read ↗

Leber’s hereditary optic neuropathy: Update on current diagnosis and treatmentSemantic proximity Read ↗

Therapeutic benefit of idebenone in patients with Leber hereditary optic neuropathy: The LEROS nonrandomized controlled trial.Semantic proximity Read ↗

Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents.Semantic proximity Read ↗

Systematic review of Leber's hereditary optic neuropathy - Clinical diagnosis, genetics overview and current concepts of treatment.Semantic proximity Read ↗

[Medical treatments in Leber's hereditary optic neuropathy].Semantic proximity Read ↗

A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy.Semantic proximity Read ↗

[Leber's hereditary optic neuropathy - phenotype, genetics, therapeutic options].Semantic proximity Read ↗

Developments in the Treatment of Leber Hereditary Optic Neuropathy.Semantic proximity Read ↗

Treatment of Leber's hereditary optic neuropathy: theory to practice.Semantic proximity Read ↗

Emerging model systems and treatment approaches for Leber's hereditary optic neuropathy: Challenges and opportunities.Semantic proximity Read ↗

Clinical trials in Leber hereditary optic neuropathy: outcomes and opportunities.Semantic proximity Read ↗

Current treatment options for treating OPA1-mutant dominant optic atrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.