Article
Treatment of advanced lung cancer based on genomic profiling using liquid biopsy (plasma): A review of three cases.
Thoracic cancer - 1 Sept 2021
Mitsumura Takahiro, Kumaki Yuichi, Takahashi Kenta, Matsudera Shotaro, Sakakibara Rie, Honda Takayuki, Ishizuka Masahiro, Iijima Yuki, Shirai Tsuyoshi, Okamoto Tsukasa, Tateishi Tomoya, Sakashita Hiroyuki, Miyake Satoshi, Ikeda Sadakatsu, Miyazaki Yasunari
Abstract excerpt
Of the 80 solid tumor cases in which liquid biopsy (LB) was performed using Guardant360 in the PROFILE study, nine were lung cancer cases. Here, we review three cases in which LB was useful in diagnosing ALK fusion-positive lung cancer, selecting sequential ALK-tyrosine kinase inhibitors, confirming uncommon EGFR mutations, and receiving biomarker-compatible therapy.
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