Article
Proposal and clinical application of molecular genetic risk scoring system, "MRplus", for BCR-ABL1 negative pediatric B-cell acute lymphoblastic leukemia- report from a single centre.
Leukemia research - 1 Dec 2021
Gupta Sanjeev Kumar, Bakhshi Sameer, Kamal Vineet Kumar, Gupta Ritu, Sharma Preity, Pushpam Deepam, Sahoo Ranjit Kumar, Sharma Atul
Abstract excerpt
INTRODUCTION: We propose "MRplus", a molecular genetic risk score and check its clinical application in the risk-stratification of pediatric B-ALL. METHODS: The genomic DNA of untreated pediatricBCR-ABL1 negative B-ALL patients was analyzed for deletions of IKZF1, PAX5, CDKN2A/B, BTG1, RB1, ETV6, EBF1, ERG, pseudoautosomal region(PAR) genes using multiplex ligation-dependent probe amplification, along with the...
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