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Article

Host Genetic Determinants Associated With Helicobacter pylori Eradication Treatment Failure: A Systematic Review and Meta-analysis.

Gastroenterology - 1 Nov 2021

Shah Shailja C, Tepler Adam, Chung Cecilia P, Suarez Giovanni, Peek Richard M, Hung Adriana, Roumie Christianne, Narula Neeraj

Abstract excerpt

BACKGROUND & AIMS: Helicobacter pylori infects approximately 50% of individuals worldwide. Successful H pylori eradication is associated with reduced risk of gastric cancer and peptic ulcer disease, among other conditions. We hypothesized that host genetic determinants, especially those affecting gastric pH, might contribute to eradication therapy failure, particularly when treatment adherence and antibiotic...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Cytochrome P-450 CYP2C19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34358488
DOI: 10.1053/j.gastro.2021.07.043
PMCID: PMC8545829

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