Article
Functional relationships between recessive inherited genes and genes with de novo variants in autism spectrum disorder.
Molecular autism - 6 Oct 2020
Wang Lin, Zhang Yi, Li Kuokuo, Wang Zheng, Wang Xiaomeng, Li Bin, Zhao Guihu, Fang Zhenghuan, Ling Zhengbao, Luo Tengfei, Xia Lu, Li Yanping, Guo Hui, Hu Zhengmao, Li Jinchen, Sun Zhongsheng, Xia Kun
Abstract excerpt
BACKGROUND: Both de novo variants and recessive inherited variants were associated with autism spectrum disorder (ASD). This study aimed to use exome data to prioritize recessive inherited genes (RIGs) with biallelically inherited variants in autosomes or X-linked inherited variants in males and investigate the functional relationships between RIGs and genes with de novo variants (DNGs). METHODS: We used a...
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