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ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes

5 Aug 2021

Abstract excerpt

The membrane protein angiotensin-converting enzyme 2 (ACE2) is a physiologic regulator of the renin-angiotensin system and the cellular receptor for the SARS-CoV-2 virus. Prior studies of ACE2 expression have primarily focused on mRNA abundance, with investigation at the protein level limited by uncertain specificity of commercial ACE2 antibodies. Here, we report our development of a sensitive and specific flow...

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PMID: 34354120
DOI: 10.1038/s41598-021-95308-9

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