Article
MAIT cell alterations in adults with recent-onset and long-term type 1 diabetes.
Diabetologia - 1 Oct 2021
Nel Isabelle, Beaudoin Lucie, Gouda Zouriatou, Rousseau Camille, Soulard Pauline, Rouland Matthieu, Bertrand Léo, Boitard Christian, Larger Etienne, Lehuen Agnès
Abstract excerpt
AIMS/HYPOTHESIS: Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes expressing an αβ T cell antigen receptor that recognises the MHC-related 1 molecule. MAIT cells are altered in children at risk for and with type 1 diabetes, and mouse model studies have shown MAIT cell involvement in type 1 diabetes development. Since several studies support heterogeneity in type 1 diabetes physiopathology...
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