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FTLD Patient–Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62

30 Jul 2021

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) is a clinically, genetically, and neuropathologically heterogeneous group of neurodegenerative syndromes, leading to progressive cognitive dysfunction and frontal and temporal atrophy. C9orf72 hexanucleotide repeat expansion (C9-HRE) is the most common genetic cause of FTLD, but pathogenic mechanisms underlying FTLD are not fully understood. Here, we compared cellular...

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PMID: 34328616
DOI: 10.1007/s12035-021-02475-x

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