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Article

Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity

20 Oct 2022

Abstract excerpt

Live-attenuated vaccines are generally highly effective. Here, we aimed to develop one against SARS-CoV-2, based on the identification of three types of temperature-sensitive (TS) strains with mutations in nonstructural proteins (nsp), impaired proliferation at 37°C–39°C, and the capacity to induce protective immunity in Syrian hamsters. To develop a live-attenuated vaccine, we generated a virus that combined all...

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PMID: 36320329
DOI: 10.1016/j.isci.2022.105412

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