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Article

Autophagy inhibition reinforces stemness together with exit from dormancy of polydisperse glioblastoma stem cells

27 Jul 2021

Abstract excerpt

Therapeutic resistance and infiltrative capacities justify the aggressiveness of glioblastoma. This is due to cellular heterogeneity, especially the presence of stemness-related cells, i.e. Cancer Stem Cells (CSC). Previous studies focused on autophagy and its role in CSCs maintenance; these studies gave conflicting results as they reported either sustaining or disruptive effects. In the present work, we silenced...

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PMID: 34314381
DOI: 10.18632/aging.203362

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