Article
Developmental phenotypic and transcriptomic effects of exposure to nanomolar levels of metformin in zebrafish.
Environmental toxicology and pharmacology - 1 Oct 2021
Phillips Jessica, Akemann Camille, Shields Jeremiah N, Wu Chia-Chen, Meyer Danielle N, Baker Bridget B, Pitts David K, Baker Tracie R
Abstract excerpt
Metformin is found in the majority of lakes and streams in the United States, leading to widespread environmental exposure. Results of the present study indicate that extended duration metformin exposure at critical developmental periods leads to decreased survival rates in zebrafish (danio rerio), an NIH approved human model. Significant abnormalities are seen with extended duration metformin exposure from 4 h...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.