Article
Allelic Variation in Protein Tyrosine Phosphatase Receptor Type-C in Cattle Influences Erythrocyte, Leukocyte and Humoral Responses to Infestation With the Cattle Tick Rhipicephalus australis.
Frontiers in immunology - 1 Jan 2021
Jonsson Nicholas N, Cox David K, Piper Emily K, Valdivieso Emily F Mantilla, Constantinoiu Constantin, Jackson Louise A, Stear Michael J, Ross Elizabeth M, Tabor Ala E
Abstract excerpt
The protein tyrosine phosphatase receptor type-C (PTPRC) gene encodes the common leukocyte antigen (CD45) receptor. CD45 affects cell adhesion, migration, cytokine signalling, cell development, and activation state. Four families of the gene have been identified in cattle: a taurine group (Family 1), two indicine groups (Families 2 and 4) and an African "taurindicine" group (Family 3). Host resistance in cattle...
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