Article
Association of somatic mutations in BRCA2 BRC domain with chemotherapy sensitivity and survival in high grade serous ovarian cancer.
Experimental cell research - 1 Sept 2021
Zhang Guonan, Zhang Jie, Zhu Yi, Liu Hong, Shi Yu, Mi Kun, Li Meiying, Zhao Qi, Huang Ziyi, Huang Jianming
Abstract excerpt
BACKGROUND: Mutations at sites crucial for the interaction between RAD51 and BRC domains impair the ability of BRCA2 homologous recombination. We aimed to clarify whether BRCA2 BRC domain-associated mutation correlates with sensibility of platinum-based chemotherapy and survival in high-grade serous ovarian cancer (HGSOC). METHODS: We identified BRCA2 BRC domain mutations by sequencing PCR-amplified amplicons of...
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