The Structural Effect of FLT3 Mutations at 835th Position and Their Interaction with Acute Myeloid Leukemia Inhibitors: In Silico Approach.

Abstract excerpt

FMS-like tyrosine kinase 3 (FLT3) gene mutations have been found in more than one-third of Acute Myeloid Leukemia (AML) cases. The most common point mutation in FLT3 occurs at the 835th residue (D835A/E/F/G/H/I/N/V/Y), in the activation loop region. The D835 residue is critical in maintaining FLT...

Topics

• Computer Simulation
• Drug Resistance, Neoplasm
• Humans
• Leukemia, Myeloid, Acute
• Molecular Docking Simulation
• Molecular Dynamics Simulation
• Mutation
• Point Mutation
• Polymorphism, Single Nucleotide
• Protein Conformation
• Protein Kinase Inhibitors
• fms-Like Tyrosine Kinase 3