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Article

Understanding gilteritinib resistance to FLT3-F691L mutation through an integrated computational strategy.

Journal of molecular modeling - 6 Aug 2022

Zhou Shibo, Yang Bo, Xu Yufeng, Gu Aihua, Peng Juan, Fu Jinfeng

Abstract excerpt

FMS-like tyrosine kinase 3 (FLT3) serves as an important drug target for acute myeloid leukemia (AML), and gene mutations of FLT3 have been closely associated with AML patients with an incidence rate of ~ 30%. However, the mechanism of the clinically relevant F691L gatekeeper mutation conferred resistance to the drug gilteritinib remained poorly understood. In this study, multiple microsecond molecular dynamics...

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Identifiers

PMID: 35932378
DOI: 10.1007/s00894-022-05254-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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