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Article

Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer

1 Jul 2021

Abstract excerpt

Novel treatment options for metastatic colorectal cancer (CRC) are urgently needed to improve patient outcome. Here, we screen a library of non-characterized small molecules against a heterogeneous collection of patient-derived CRC spheroids. By prioritizing compounds with inhibitory activity in a subset of-but not all-spheroid cultures, NCT02 is identified as a candidate with minimal risk of non-specific...

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PMID: 34289372
DOI: 10.1016/j.celrep.2021.109394

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