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Article

A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle.

PLoS genetics - 1 Jul 2021

Lee Young-Lim, Takeda Haruko, Costa Monteiro Moreira Gabriel, Karim Latifa, Mullaart Erik, Coppieters Wouter, Appeltant Ruth, Veerkamp Roel F, Groenen Martien A M, Georges Michel, Bosse Mirte, Druet Tom, Bouwman Aniek C, Charlier Carole

Abstract excerpt

Clinical mastitis (CM) is an inflammatory disease occurring in the mammary glands of lactating cows. CM is under genetic control, and a prominent CM resistance QTL located on chromosome 6 was reported in various dairy cattle breeds. Nevertheless, the biological mechanism underpinning this QTL has been lacking. Herein, we mapped, fine-mapped, and discovered the putative causal variant underlying this CM resistance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Linkage Disequilibrium

Share to Mastitis, Bovine

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Identifiers

PMID: 34288907
DOI: 10.1371/journal.pgen.1009331
PMCID: PMC8328317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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