Article
Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/β2 -AR/MACC1 axis.
Cancer communications (London, England) - 1 Oct 2021
Pan Changqie, Wu Jianhua, Zheng Siting, Sun Huiying, Fang Yisheng, Huang Zhenhua, Shi Min, Liang Li, Bin Jianping, Liao Yulin, Chen Jinzhang, Liao Wangjun
Abstract excerpt
BACKGROUND: Depression is a common, easily ignored, accompanied disease of gastric cancer (GC) patients and is often observed with elevated plasma catecholamine levels. Depression frequently promotes GC progression and leads to poor clinical outcomes; however, the molecular mechanisms underlying depression-induced GC progression remain poorly understood. We aimed to study the effects of depression on GC...
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