Article
High-throughput compound screening identifies navitoclax combined with irradiation as a candidate therapy for HPV-negative head and neck squamous cell carcinoma.
Scientific reports - 20 Jul 2021
Tuomainen Katja, Hyytiäinen Aini, Al-Samadi Ahmed, Ianevski Philipp, Ianevski Aleksandr, Potdar Swapnil, Turunen Laura, Saarela Jani, Kuznetsov Sergey, Wahbi Wafa, Risteli Maija, Mäkitie Antti, Monni Outi, Salo Tuula
Abstract excerpt
Conventional chemotherapeutic agents are nonselective, often resulting in severe side effects and the development of resistance. Therefore, new molecular-targeted therapies are urgently needed to be integrated into existing treatment regimens. Here, we performed a high-throughput compound screen to identify a synergistic interaction between ionizing radiation and 396 anticancer compounds. The assay was run using...
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