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Epigenetic Effects of Blackberry Extract on Human Colorectal Cancer Cells

20 Jul 2021

Abstract excerpt

Fruit-derived polyphenolic compounds have been shown to exert anticancer effects via epigenetic mechanisms. In this study, we investigated the effect of blackberry extract on the expression of DNMTs (Dnmt1, Dnmt3a, and Dnmt3b) and HDACs (HDAC1-4 and SIRT1) and its influence on the cellular differentiation and promoter DNA methylation of tumor-related genes using a panel of six human CRC cell lines. Treatment with...

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PMID: 34282673
DOI: 10.1080/01635581.2021.1952454

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