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Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19

19 Jul 2021

Abstract excerpt

BACKGROUND: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has been associated with neurological and neuropsychiatric illness in many individuals. We sought to further our understanding of the relationship between brain tropism, neuro-inflammation, and host immune response in acute COVID-19 cases. METHODS: Three brain regions (dorsolateral...

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PMID: 34281603
DOI: 10.1186/s13073-021-00933-8

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