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Article

Genetic risk for chronic pain is associated with lower antidepressant effectiveness: Converging evidence for a depression subtype.

The Australian and New Zealand journal of psychiatry - 1 Sept 2022

Campos Adrián I, Ngo Trung Thanh, Medland Sarah E, Wray Naomi R, Hickie Ian B, Byrne Enda M, Martin Nicholas G, Rentería Miguel E

Abstract excerpt

INTRODUCTION: Chronic pain and depression are highly comorbid and difficult-to-treat disorders. We previously showed this comorbidity is associated with higher depression severity, lower antidepressant treatment effectiveness and poorer prognosis in the Australian Genetics of Depression Study. OBJECTIVE: The current study aimed to assess whether a genetic liability to chronic pain is associated with...

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PMID: 34266302
DOI: 10.1177/00048674211031491

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