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Incorporating Differential Gene Expression Analysis with Predictive Biomarkers to Identify Novel Therapeutic Drugs for Fuchs Endothelial Corneal Dystrophy

1 Jan 2021

Abstract excerpt

Purpose . Based on the differential gene expression analysis for predictive biomarkers with RNA‐Sequencing data from Fuchs endothelial corneal dystrophy (FECD) patients, we are aiming to evaluate the efficacy of Library of Integrated Network‐based Cellular Signatures (LINCS) perturbagen prediction software to identify novel pharmacotherapeutic targets that can revert the pathogenic gene expression signatures and...

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PMID: 34258047
DOI: 10.1155/2021/5580595

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