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Article

Dysregulation of theTCF4Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy

17 Jun 2024

Abstract excerpt

Purpose: This study evaluated the dysregulation of TCF4 isoforms and differential exon usage (DEU) in corneal endothelial cells (CECs) of Fuchs endothelial corneal dystrophy (FECD) with or without trinucleotide repeat (TNR) expansion in the intron region of the TCF4 gene. Methods: Three RNA-Seq datasets of CECs (our own and two other previously published datasets) derived from non-FECD control and FECD subjects...

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Identifiers

PMID: 38884552
DOI: 10.1167/iovs.65.6.27

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