Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paraganglioma and other tumour detection rates in individuals with SDHx pathogenic variants by age of diagnosis and after the age of 50.

Clinical endocrinology - 1 Sept 2021

Greenberg Samantha E, Holman Rachel, Kohlmann Wendy, Buchmann Luke, Naumer Anne

Abstract excerpt

OBJECTIVE: Patients with SDHx germline mutations (SDHA, AF2, B, C, D) are at risk for paragangliomas (PGLs), renal cell carcinoma and gastrointestinal stromal tumours. The aim of this study was to evaluate the age of SDHx tumour diagnosis in those with pathogenic variants (PVs), notably tumour detection after the age of 50 years. STUDY DESIGN: Longitudinal retrospective observational analysis. PATIENTS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Gland Neoplasms
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Paraganglioma

Share to Pheochromocytoma

Share to Succinate Dehydrogenase

Source

Identifiers

PMID: 34255389
DOI: 10.1111/cen.14559

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paraganglioma and other tumour detection rates in individuals with SDHx pathogenic variants by age of diagnosis and after the age of 50.PMID 34255389Read ↗

UK recommendations for SDHA germline genetic testing and surveillance in clinical practice.Semantic proximity Read ↗

15 YEARS OF PARAGANGLIOMA: Clinical manifestations of paraganglioma syndromes types 1–5Semantic proximity Read ↗

International consensus on initial screening and follow-up of asymptomatic SDHx mutation carriersSemantic proximity Read ↗

Clinical Aspects of SDHA-Related Pheochromocytoma and Paraganglioma: A Nationwide Study.Semantic proximity Read ↗

Tumor detection rates in screening of individuals with SDHx-related hereditary paraganglioma–pheochromocytoma syndromeSemantic proximity Read ↗

Clinical characteristics and prognosis of SDHD pathogenic variant carriers: a systematic review and meta-analysis.Semantic proximity Read ↗

Pathogenicity and Penetrance of Germline SDHA Variants in Pheochromocytoma and Paraganglioma (PPGL)Semantic proximity Read ↗

Positive Impact of Genetic Test on the Management and Outcome of Patients With Paraganglioma and/or PheochromocytomaSemantic proximity Read ↗

Surveillance Improves Outcomes for Carriers of SDHB Pathogenic Variants: A Multicenter Study.Semantic proximity Read ↗

Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD.Semantic proximity Read ↗

Rapid-sequence MRI for long-term surveillance for paraganglioma and phaeochromocytoma in patients with succinate dehydrogenase mutations.Semantic proximity Read ↗

[Hereditary pheochromocytoma and paraganglioma: screening and follow-up strategies in asymptomatic mutation carriers].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.