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Article

Clinical characteristics and prognosis of SDHD pathogenic variant carriers: a systematic review and meta-analysis.

Journal of medical genetics - 23 Jul 2026

Lian Xinquan, Shen Liping, Song Jiayin, Pang Mengqi, Zhong Yunmeng, Zhang Han, Xing Yadong, Tung Tao-Hsin, Shen Bo

Abstract excerpt

BACKGROUND: Germline pathogenic variants (PVs) of succinate dehydrogenase subunit D (SDHD) are major genetic causes of pheochromocytomas and paragangliomas. Existing studies have reported inconsistent findings and lack a comprehensive synthesis regarding penetrance, multifocality and metastatic risk in carriers of SDHD PVs. OBJECTIVE: To systematically assess age-specific penetrance (in all carriers) and the...

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Share to Adrenal Gland Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41986136
DOI: 10.1136/jmg-2025-111235
PMCID: PMC13479636

Genes

SDHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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