Article
Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype.
Frontiers in immunology - 1 Jan 2021
Trombetta Amelia C, Farias Guilherme B, Gomes André M C, Godinho-Santos Ana, Rosmaninho Pedro, Conceição Carolina M, Laia Joel, Santos Diana F, Almeida Afonso R M, Mota Catarina, Gomes Andreia, Serrano Marta, Veldhoen Marc, Sousa Ana E, Fernandes Susana M
Abstract excerpt
After more than one year since the COVID-19 outbreak, patients with severe disease still constitute the bottleneck of the pandemic management. Aberrant inflammatory responses, ranging from cytokine storm to immune-suppression, were described in COVID-19 and no treatment was demonstrated to change the prognosis significantly. Therefore, there is an urgent need for understanding the underlying pathogenic mechanisms...
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