Article
The molecular basis for SARS-CoV-2 binding to dog ACE2.
Nature communications - 7 Jul 2021
Zhang Zengyuan, Zhang Yanfang, Liu Kefang, Li Yan, Lu Qiong, Wang Qingling, Zhang Yuqin, Wang Liang, Liao Hanyi, Zheng Anqi, Ma Sufang, Fan Zheng, Li Huifang, Huang Weijin, Bi Yuhai, Zhao Xin, Wang Qihui, Gao George F, Xiao Haixia, Tong Zhou, Qi Jianxun, Sun Yeping
Abstract excerpt
SARS-CoV-2 can infect many domestic animals, including dogs. Herein, we show that dog angiotensin-converting enzyme 2 (dACE2) can bind to the SARS-CoV-2 spike (S) protein receptor binding domain (RBD), and that both pseudotyped and authentic SARS-CoV-2 can infect dACE2-expressing cells. We solved the crystal structure of RBD in complex with dACE2 and found that the total number of contact residues, contact atoms,...
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