Article

The molecular basis for SARS-CoV-2 recognized by dog ACE2

2021-03-02

Abstract excerpt

SARS-CoV-2 can infect many domestic animals, including dogs. Herein, we show that dog angiotensin converting enzyme 2 (dACE2) can bind to SARS-CoV-2 spike (S) protein receptor binding region (RBD), and that both pseudotyped and authentic SARS-CoV-2 can infect dACE2-expressing cells. we solved the crystal structure of RBD in complex with dACE2 and found that the total numbers of contact residues, contact atoms, hyd...

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Literature Corpus work: e112a481-2e30-5b50-8155-fb79d39e7918
DOI: 10.21203/rs.3.rs-263301/v1

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