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Elevated cell‐free fetal DNA contributes to placental inflammation and antiangiogenesis via AIM2 and IFI16 during pre‐eclampsia

7 May 2020

Abstract excerpt

Accumulated evidence has shown that pre-eclampsia (PE) is related to both maternal and utero-placental antiangiogenesis and inflammation. Remarkably, an elevated cell-free fetal DNA (cffDNA) level has been found in maternal circulation; however, it remains unclear whether this DNA can induce activation of cytosolic DNA sensor signaling pathways and lead to the development of PE. In this study, we found that...

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PMID: 32383175
DOI: 10.1002/jcp.29766

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