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W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34.

Molecular neurobiology - 1 Oct 2021

Nagaraja Raghavendra Y, Sherry David M, Fessler Jennifer L, Stiles Megan A, Li Feng, Multani Karanpreet, Orock Albert, Ahmad Mohiuddin, Brush Richard S, Anderson Robert E, Agbaga Martin-Paul, Deák Ferenc

Abstract excerpt

Spinocerebellar ataxia (SCA) is a neurodegenerative disorder characterized by ataxia and cerebellar atrophy. A number of different mutations gives rise to different types of SCA with characteristic ages of onset, symptomatology, and rates of progression. SCA type 34 (SCA34) is caused by mutations in ELOVL4 (ELOngation of Very Long-chain fatty acids 4), a fatty acid elongase essential for biosynthesis of Very Long...

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PMID: 34227061
DOI: 10.1007/s12035-021-02439-1
PMCID: PMC8497303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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