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Article

Two-Sample Mendelian Randomization Analysis of Associations Between Periodontal Disease and Risk of Cancer.

JNCI cancer spectrum - 1 Jun 2021

Corlin Laura, Ruan Mengyuan, Tsilidis Konstantinos K, Bouras Emmanouil, Yu Yau-Hua, Stolzenberg-Solomon Rachael, Klein Alison P, Risch Harvey A, Amos Christopher I, Sakoda Lori C, Vodička Pavel, Rish Pai K, Beck James, Platz Elizabeth A, Michaud Dominique S

Abstract excerpt

Background: Observational studies indicate that periodontal disease may increase the risk of colorectal, lung, and pancreatic cancers. Using a 2-sample Mendelian randomization (MR) analysis, we assessed whether a genetic predisposition index for periodontal disease was associated with colorectal, lung, or pancreatic cancer risks. Methods: Our primary instrument included single nucleotide polymorphisms with strong...

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Identifiers

PMID: 34222791
DOI: 10.1093/jncics/pkab037
PMCID: PMC8242136

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