Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer.

doi:10.3390/ijms22136652

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Article

Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer.

International journal of molecular sciences - 22 Jun 2021

Battista Serena, Ambrosio Maria Raffaella, Limarzi Francesco, Gallo Graziana, Saragoni Luca

Abstract excerpt

Prognosis of gastric cancer is dramatically improved by early diagnosis. Correa's cascade correlates the expression of some molecular markers with the progression of preneoplastic lesions toward carcinoma. This article reviews the diagnostic and prognostic values of molecular markers in complete (MUC2) and incomplete (MUC2, MUC5AC, and MUC6) intestinal metaplasia, gastric dysplasia/intra-epithelial neoplasia, and...

Topics

Biomarkers, Tumor
Early Detection of Cancer
GATA6 Transcription Factor
Gene Expression Regulation, Neoplastic
Humans
Intestines
Metaplasia
Mucin 5AC
Mucin-2
Mucin-6
Mutation
Prognosis
Stomach Neoplasms
Tumor Suppressor Protein p53

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Open in PubMed Open full text

Identifiers

PMID: 34206291
DOI: 10.3390/ijms22136652
PMCID: PMC8268370

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