Maternal Folic Acid Intake and Methylation Status of Genes Associated with Ventricular Septal Defects in Children: Case-Control Study.

doi:10.3390/nu13062071

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Article

Maternal Folic Acid Intake and Methylation Status of Genes Associated with Ventricular Septal Defects in Children: Case-Control Study.

Nutrients - 17 Jun 2021

González-Peña Sandra M, Calvo-Anguiano Geovana, Martínez-de-Villarreal Laura E, Ancer-Rodríguez Patricia R, Lugo-Trampe José J, Saldivar-Rodríguez Donato, Hernández-Almaguer María D, Calzada-Dávila Melissa, Guerrero-Orjuela Ligia S, Campos-Acevedo Luis D

Abstract excerpt

BACKGROUND: DNA methylation is the best epigenetic mechanism for explaining the interactions between nutrients and genes involved in intrauterine growth and development programming. A possible contributor of methylation abnormalities to congenital heart disease is the folate methylation regulatory pathway; however, the mechanisms and methylation patterns of VSD-associated genes are not fully understood....

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PMID: 34204335
DOI: 10.3390/nu13062071
PMCID: PMC8234530

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