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Article

Application of single cell genomics to focal epilepsies: A call to action.

Brain pathology (Zurich, Switzerland) - 1 Jul 2021

Khoshkhoo Sattar, Lal Dennis, Walsh Christopher A

Abstract excerpt

Focal epilepsies are the largest epilepsy subtype and associated with significant morbidity. Somatic variation is a newly recognized genetic mechanism underlying a subset of focal epilepsies, but little is known about the processes through which somatic mosaicism causes seizures, the cell types carrying the pathogenic variants, or their developmental origin. Meanwhile, the inception of single cell biology has...

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PMID: 34196990
DOI: 10.1111/bpa.12958
PMCID: PMC8412079

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