Article
Upregulation of GBP1 in thyroid primordium is required for developmental thyroid morphogenesis.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Oct 2021
Yang Rui-Meng, Zhan Ming, Zhou Qin-Yi, Ye Xiao-Ping, Wu Feng-Yao, Dong Mei, Sun Feng, Fang Ya, Zhang Rui-Jia, Zhang Chang-Run, Yang Liu, Guo Miao-Miao, Zhang Jun-Xiu, Liang Jun, Cheng Feng, Liu Wei, Han Bing, Zhou Yi, Zhao Shuang-Xia, Song Huai-Dong
Abstract excerpt
PURPOSE: Congenital hypothyroidism (CH) is a common congenital endocrine disorder in humans. CH-related diseases such as athyreosis, thyroid ectopy, and hypoplasia are primarily caused by dysgenic thyroid development. However, the underlying molecular mechanisms remain unknown. METHODS: To identify novel CH candidate genes, 192 CH patients were enrolled, and target sequencing of 21 known CH-related genes was...
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