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Article

α2δ-1-Dependent NMDA Receptor Activity in the Hypothalamus Is an Effector of Genetic-Environment Interactions That Drive Persistent Hypertension.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Jul 2021

Zhou Jing-Jing, Shao Jian-Ying, Chen Shao-Rui, Li De-Pei, Pan Hui-Lin

Abstract excerpt

The interplay between genetic and environmental factors is critically involved in hypertension development. The paraventricular nucleus (PVN) of the hypothalamus regulates sympathetic output during stress responses and chronic hypertension. In this study, we determined mechanisms of synaptic plasticity in the PVN in chronic stress-induced persistent hypertension in male borderline hypertensive rats (BHR), the...

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Source

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Identifiers

PMID: 34193557
DOI: 10.1523/JNEUROSCI.0346-21.2021
PMCID: PMC8318080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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