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Article

Comprehensive Proteomics Profiling Reveals Circulating Biomarkers of Hypertrophic Cardiomyopathy.

Circulation. Heart failure - 1 Jul 2021

Shimada Yuichi J, Raita Yoshihiko, Liang Lusha W, Maurer Mathew S, Hasegawa Kohei, Fifer Michael A, Reilly Muredach P

Abstract excerpt

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is caused by mutations in the genes coding for proteins essential in normal myocardial contraction. However, it remains unclear through which molecular pathways gene mutations mediate the development of HCM. The objectives were to determine plasma protein biomarkers of HCM and to reveal molecular pathways differentially regulated in HCM. METHODS: We conducted a...

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Identifiers

PMID: 34192899
DOI: 10.1161/CIRCHEARTFAILURE.120.007849
PMCID: PMC8292216

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