SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2.

doi:10.1016/j.cell.2021.06.005

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SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2.

Cell - 22 Jul 2021

Amanat Fatima, Thapa Mahima, Lei Tinting, Ahmed Shaza M Sayed, Adelsberg Daniel C, Carreño Juan Manuel, Strohmeier Shirin, Schmitz Aaron J, Zafar Sarah, Zhou Julian Q, Rijnink Willemijn, Alshammary Hala, Borcherding Nicholas, Reiche Ana Gonzalez, Srivastava Komal, Sordillo Emilia Mia, van Bakel Harm, Turner Jackson S, Bajic Goran, Simon Viviana, Ellebedy Ali H, Krammer Florian

Abstract excerpt

In this study we profiled vaccine-induced polyclonal antibodies as well as plasmablast-derived mAbs from individuals who received SARS-CoV-2 spike mRNA vaccine. Polyclonal antibody responses in vaccinees were robust and comparable to or exceeded those seen after natural infection. However, the ratio of binding to neutralizing antibodies after vaccination was greater than that after natural infection and, at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34192529
DOI: 10.1016/j.cell.2021.06.005
PMCID: PMC8185186

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