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Article

Immunometabolism: A 'Hot' Switch for 'Cold' Pediatric Solid Tumors.

Trends in cancer - 1 Aug 2021

Xiao Lin, Yeung Harrison, Haber Michelle, Norris Murray D, Somers Klaartje

Abstract excerpt

Despite the success of immunotherapies in adult solid cancers and pediatric hematological malignancies, limited progress has been made towards implementing these strategies in pediatric solid tumors. These tumors exhibit a high potential to escape antitumor immunity, making them difficult to target by current immunotherapies. This review highlights the altered metabolic pathways in pediatric solid tumors that...

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Share to Antigens, Neoplasm
Share to Antimetabolites, Antineoplastic
Share to Immune Checkpoint Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Metabolic Networks and Pathways

Share to Tumor Escape

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Source

Identifiers

PMID: 34183305
DOI: 10.1016/j.trecan.2021.05.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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