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Article

Molecular determinants of response to PD-L1 blockade across tumor types.

Nature communications - 25 Jun 2021

Banchereau Romain, Leng Ning, Zill Oliver, Sokol Ethan, Liu Gengbo, Pavlick Dean, Maund Sophia, Liu Li-Fen, Kadel Edward, Baldwin Nicole, Jhunjhunwala Suchit, Nickles Dorothee, Assaf Zoe June, Bower Daniel, Patil Namrata, McCleland Mark, Shames David, Molinero Luciana, Huseni Mahrukh, Sanjabi Shomyseh, Cummings Craig, Mellman Ira, Mariathasan Sanjeev, Hegde Priti, Powles Thomas

Abstract excerpt

Immune checkpoint inhibitors targeting the PD-1/PD-L1 axis lead to durable clinical responses in subsets of cancer patients across multiple indications, including non-small cell lung cancer (NSCLC), urothelial carcinoma (UC) and renal cell carcinoma (RCC). Herein, we complement PD-L1 immunohistochemistry (IHC) and tumor mutation burden (TMB) with RNA-seq in 366 patients to identify unifying and...

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Identifiers

PMID: 34172722
DOI: 10.1038/s41467-021-24112-w
PMCID: PMC8233428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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