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mRNA therapeutics: beyond vaccine applications

23 Jun 2021

Abstract excerpt

The basic principle of mRNA therapeutics involves delivery of in vitro transcribed mRNA into a target cell, where cellular machinery translates the mRNA into a functional protein. In vaccine applications, an mRNA encoding a viral protein will elicit a protective immune response, whereas in therapeutic applications, an mRNA encoding an absent (or dysfunctional) protein in a patient provides functional protein...

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PMID: 34172390
DOI: 10.1016/j.molmed.2021.05.004

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