Article
Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain.
Genetic epidemiology - 1 Oct 2021
Hahn Georg, Wu Chloe M, Lee Sanghun, Lutz Sharon M, Khurana Surender, Baden Lindsey R, Haneuse Sebastien, Qiao Dandi, Hecker Julian, DeMeo Dawn L, Tanzi Rudolph E, Choudhary Manish C, Etemad Behzad, Mohammadi Abbas, Esmaeilzadeh Elmira, Cho Michael H, Li Jonathan Z, Randolph Adrienne G, Laird Nan M, Weiss Scott T, Silverman Edwin K, Ribbeck Katharina, Lange Christoph
Abstract excerpt
SARS-CoV-2 mortality has been extensively studied in relation to host susceptibility. How sequence variations in the SARS-CoV-2 genome affect pathogenicity is poorly understood. Starting in October 2020, using the methodology of genome-wide association studies (GWAS), we looked at the association between whole-genome sequencing (WGS) data of the virus and COVID-19 mortality as a potential method of early...
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