Article
Automated capture-based NGS workflow: one thousand patients experience in a clinical routine framework.
Diagnosis (Berlin, Germany) - 16 Jun 2021
Tenedini Elena, Celestini Fabio, Iapicca Pierluigi, Marino Marco, Castellano Sara, Artuso Lucia, Biagiarelli Fiammetta, Cortesi Laura, Toss Angela, Barbieri Elena, Roncucci Luca, Pedroni Monica, Manfredini Rossella, Luppi Mario, Trenti Tommaso, Tagliafico Enrico
Abstract excerpt
OBJECTIVES: The Next Generation Sequencing (NGS) based mutational study of hereditary cancer genes is crucial to design tailored prevention strategies in subjects with different hereditary cancer risk. The ease of amplicon-based NGS library construction protocols contrasts with the greater uniformity of enrichment provided by capture-based protocols and so with greater chances for detecting larger genomic...
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