Article
Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype.
Microbiome - 14 Jun 2021
Li Jia V, Ashrafian Hutan, Sarafian Magali, Homola Daniel, Rushton Laura, Barker Grace, Cabrera Paula Momo, Lewis Matthew R, Darzi Ara, Lin Edward, Gletsu-Miller Nana Adwoa, Atkin Stephen L, Sathyapalan Thozhukat, Gooderham Nigel J, Nicholson Jeremy K, Marchesi Julian R, Athanasiou Thanos, Holmes Elaine
Abstract excerpt
BACKGROUND: Bariatric surgery, used to achieve effective weight loss in individuals with severe obesity, modifies the gut microbiota and systemic metabolism in both humans and animal models. The aim of the current study was to understand better the metabolic functions of the altered gut microbiome by conducting deep phenotyping of bariatric surgery patients and bacterial culturing to investigate causality of the...
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